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Family					Level	# members	# members with tested compounds	# members with 3D structures	# members with Druggable 3D structures
AGC Ser/Thr protein kinase family					family	58	54	39	27
AB hydrolase superfamily					superfamily	51	22	15	10
ABC transporter superfamily					superfamily	49	17	14	14
AAA ATPase family					family	35	6	18	12
actin family					family	28	2	9	6
Arf family					family	27	3	11	4
ATP-dependent AMP-binding enzyme family					family	27	4	2	1
Antp homeobox family					family	26	0	2	0
Adhesion G-protein coupled receptor (ADGR) subfamily					subfamily	25	0	3	1
adenylyl cyclase class-4/guanylyl cyclase family					family	19	17	3	2
acetyltransferase family					family	19	3	11	11
ankyrin SOCS box (ASB) family					family	18	0	2	1
amino acid/polyamine transporter 2 family					family	16	1	0	0
Acetylcholine receptor (TC 1.A.9.1) subfamily					subfamily	16	16	7	4
alpha/beta interferon family					family	16	0	4	3
alpha-carbonic anhydrase family					family	16	13	11	11
Abd-B homeobox family					family	16	0	4	0
aldehyde dehydrogenase family					family	16	8	9	9
aldo/keto reductase family					family	15	7	10	10
amino acid-polyamine-organocation (APC) superfamily					superfamily	15	2	0	0
annexin family					family	14	1	8	6
ATF subfamily					subfamily	13	1	1	0
ABCC family					family	12	11	3	3
ABCA family					family	12	0	1	1
ADIPOR family					family	11	0	2	2
adaptor complexes large subunit family					family	11	0	6	3
ABCB family					family	11	5	6	6
acyl-CoA dehydrogenase family					family	11	0	8	8
arrestin family					family	10	0	3	1
anion exchanger (TC 2.A.31) family					family	10	0	3	2
anoctamin family					family	10	1	1	1
adenylate kinase family					family	9	4	7	6
amiloride-sensitive sodium channel (TC 1.A.6) family					family	9	5	1	0
Adrenergic receptor subfamily					subfamily	9	9	3	1
adaptor complexes small subunit family					family	9	0	4	2
argonaute family					family	8	0	5	3
alkB family					family	8	1	5	4
ATG8 family					family	8	0	6	5
AIG1/Toc34/Toc159-like paraseptin GTPase family					family	8	0	4	2
actin-binding proteins ADF family					family	8	1	5	2
A (Shaker) (TC 1.A.1.2) subfamily					subfamily	8	7	3	0
adaptor complexes medium subunit family					family	8	0	2	2
apolipoprotein L family					family	7	0	0	0
Alpha-type (group II) subfamily					subfamily	7	0	1	0
Adenosine and AMP deaminases family					family	6	5	3	1
Alpha family					family	5	4	4	4
ANP32 family					family	5	0	3	0
AP-2 family					family	5	0	0	0
ADCK protein kinase family					family	5	2	1	1
ABCG family					family	5	1	3	3
ammonium transporter (TC 2.A.49) family					family	5	0	1	0
alpha-defensin family					family	5	0	5	1
activator 1 small subunits family					family	5	0	0	0
ATPase alpha/beta chains family					family	5	4	0	0
AhpC/Prx1 subfamily					subfamily	4	1	4	2
AF4 family					family	4	0	2	0
Ago subfamily					subfamily	4	0	3	3
Atypical chemokine receptor subfamily					subfamily	4	2	1	0
AB hydrolase 4 family					family	4	0	0	0
aggrecan/versican proteoglycan family					family	4	0	1	0
alpha-actinin family					family	4	0	4	2
archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family					family	4	0	1	1
aldolase class II family					family	4	0	1	0
Alpha-type protein kinase family					family	4	1	2	1
alkaline phosphatase family					family	4	4	1	0
acyl-CoA oxidase family					family	4	0	0	0
ATP:guanido phosphotransferase family					family	4	2	4	4
ALB/AFP/VDB family					family	4	2	4	3
AKAP110 family					family	4	0	0	0
Arg-specific ADP-ribosyltransferase family					family	4	1	0	0
A subfamily					subfamily	4	0	3	0
ABCD family					family	4	0	0	0
apolipoprotein A1/A4/E family					family	4	1	3	0
APG1/unc-51/ULK1 subfamily					subfamily	4	3	2	2
ACDP family					family	4	0	3	1
acid sphingomyelinase family					family	3	1	2	1
Asx family					family	3	0	0	0
archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family					family	3	0	1	0
angiomotin family					family	3	0	0	0
ATP-dependent PFK group I subfamily					subfamily	3	1	2	2
Aurora subfamily					subfamily	3	3	2	2
amidase family					family	3	2	0	0
ATPase C chain family					family	3	0	3	0
AXL/UFO subfamily					subfamily	3	3	3	2
ANKRD34 family					family	3	0	0	0
APP family					family	3	1	3	2
ALPK subfamily					subfamily	3	0	1	1
AB hydrolase 2 family					family	3	3	3	1
ABI family					family	3	0	1	0
aspartyl/asparaginyl beta-hydroxylase family					family	3	0	1	1
AQP11/AQP12 subfamily					subfamily	3	0	0	0
Adducin subfamily					subfamily	3	0	0	0
aconitase/IPM isomerase family					family	3	0	1	1
adrenomedullin family					family	3	2	1	0
ASPP family					family	3	0	2	0
arginase family					family	3	2	2	2
ABCF family					family	3	0	1	1
alkaline ceramidase family					family	3	1	0	0
adenosylhomocysteinase family					family	3	1	3	3
Amer family					family	3	0	1	0
ANKRD36 family					family	3	0	0	0
ADP-ribosylglycohydrolase family					family	3	0	2	1
ATP-dependent DNA ligase family					family	3	1	3	3
ABHD17 family					family	3	1	0	0
ATR family					family	3	0	2	2
AXUD1 family					family	3	0	0	0
ARD1 subfamily					subfamily	3	0	1	1
alpha-ketoglutarate dehydrogenase family					family	3	1	1	0
AKAP95 family					family	3	0	0	0
Aldo/keto reductase 2 subfamily					subfamily	3	0	2	2
AMIGO family					family	3	0	0	0
Aspartoacylase subfamily					subfamily	2	0	1	1
AGR family					family	2	0	2	1
ataxin-2 family					family	2	0	1	0
AIG1 family					family	2	0	0	0
ABHD14 family					family	2	0	1	0
acid ceramidase family					family	2	2	1	1
ABHD16 family					family	2	1	0	0
amelogenin family					family	2	0	0	0
Ariadne subfamily					subfamily	2	0	1	1
ATM subfamily					subfamily	2	2	2	2
ARP3 subfamily					subfamily	2	0	1	1
Alanine aminotransferase subfamily					subfamily	2	1	1	0
arylamine N-acetyltransferase family					family	2	2	2	2
adipolin/erythroferrone family					family	2	0	0	0
astrotactin family					family	2	0	1	0
ADAD family					family	2	0	0	0
ARMET family					family	2	0	2	0
adenomatous polyposis coli (APC) family					family	2	1	1	1
archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family					family	2	0	1	1
adenylosuccinate synthetase family					family	2	1	1	1
ATG2 family					family	2	0	0	0
AUTS2 family					family	2	0	0	0
AspA/AstE family					family	2	0	1	1
ARPC5 family					family	2	0	0	0
ALG6/ALG8 glucosyltransferase family					family	2	0	0	0
ATPase g subunit family					family	2	0	0	0
APH-1 family					family	2	2	1	1
ALG10 glucosyltransferase family					family	2	0	0	0
ABHD4/ABHD5 subfamily					subfamily	2	0	0	0
ATP synthase subunit s family					family	2	0	0	0
acylphosphatase family					family	2	0	1	1
ADP-ribosyl cyclase family					family	2	1	2	2
ATG9 family					family	2	0	0	0
apolipoprotein O/MICOS complex subunit Mic27 family					family	2	0	0	0
AK3 subfamily					subfamily	2	1	2	2
akirin family					family	2	0	0	0
AKR/ZDHHC17 subfamily					subfamily	2	0	1	0
ARP1 subfamily					subfamily	2	0	1	1
AVIT (prokineticin) family					family	2	0	0	0
AFG2 subfamily					subfamily	2	1	0	0
adrenodoxin/putidaredoxin family					family	2	0	2	1
AHA1 family					family	2	0	1	0
ABL subfamily					subfamily	2	2	2	2
ALKAL family					family	2	0	0	0
AccD/PCCB family					family	2	0	0	0
AdoMet synthase family					family	2	0	2	0
ATXN1 family					family	2	0	1	1
Arkadia family					family	2	0	2	0
ASF1 family					family	2	0	2	0
anamorsin family					family	1	0	1	1
Alpha-2/CHRNA2 sub-subfamily					subsubfamily	1	1	1	0
AMY1 family					family	1	0	1	0
apolipoprotein A2 family					family	1	0	0	0
ADRB2 sub-subfamily					subsubfamily	1	1	1	1
apyrase family					family	1	0	1	1
AANAT subfamily					subfamily	1	0	0	0
ATPase epsilon chain family					family	1	0	0	0
acireductone dioxygenase (ARD) family					family	1	0	1	0
APC10 family					family	1	0	1	0
AK1 subfamily					subfamily	1	1	1	1
adipogenin family					family	1	0	0	0
Alpha-3/CHRNA3 sub-subfamily					subsubfamily	1	1	1	0
AK6 subfamily					subfamily	1	0	1	1
Argininosuccinate lyase subfamily					subfamily	1	0	1	1
ASIC2 subfamily					subfamily	1	0	0	0
ARID5B family					family	1	0	1	0
ataxin-7 family					family	1	0	1	0
ATX1 family					family	1	0	1	1
ATPase gamma chain family					family	1	0	0	0
archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family					family	1	0	1	0
APC1 family					family	1	0	1	1
ADPRibase-Mn family					family	1	0	0	0
ANF homeobox family					family	1	0	1	0
ASIC5 subfamily					subfamily	1	0	0	0
activator 1 large subunit family					family	1	0	1	0
AGK family					family	1	1	0	0
AEBP2/jing C2H2-type zinc-finger family					family	1	1	1	0
ATG3 family					family	1	0	1	0
aminoglycoside phosphotransferase family					family	1	0	0	0
ADP-dependent glucokinase family					family	1	0	0	0
Arpin family					family	1	0	1	0
ASIC1 subfamily					subfamily	1	1	0	0
ATG14 family					family	1	0	0	0
APC7 family					family	1	0	1	1
acyl carrier protein (ACP) family					family	1	0	1	1
ADAT1 family					family	1	0	0	0
ATP12 family					family	1	0	0	0
apelin family					family	1	1	0	0
ARL2BP family					family	1	0	1	1
ADAT2 subfamily					subfamily	1	0	1	0
Adenylosuccinate lyase subfamily					subfamily	1	0	1	1
AK2 subfamily					subfamily	1	1	1	1
ATG17 family					family	1	0	0	0
APC6/CDC16 family					family	1	0	1	1
ATG5 family					family	1	0	1	1
API5 family					family	1	0	1	0
AAED1 family					family	1	0	0	0
ADRB1 sub-subfamily					subsubfamily	1	1	1	0
ATG10 family					family	1	0	0	0
APC5 family					family	1	0	1	1
AHSP family					family	1	0	1	0
ANKRD39 family					family	1	0	0	0
asunder family					family	1	0	0	0
ALAD family					family	1	1	1	1
AIDA family					family	1	0	0	0
apolipoprotein F family					family	1	0	0	0
aldose epimerase family					family	1	0	1	1
ataxin-10 family					family	1	0	0	0
APLF family					family	1	0	1	1
Alpha-7/CHRNA7 sub-subfamily					subsubfamily	1	1	1	1
Arsenite methyltransferase family					family	1	0	0	0
ADRB3 sub-subfamily					subsubfamily	1	1	0	0
ADIP family					family	1	0	0	0
AcpS family					family	1	1	1	1
Abro1 subfamily					subfamily	1	0	0	0
ATG101 family					family	1	0	1	1
APOPT family					family	1	0	0	0
Alpha-9/CHRNA9 sub-subfamily					subsubfamily	1	1	1	1
ARP8 subfamily					subfamily	1	0	1	0
ARL6IP6 family					family	1	0	0	0
apolipoprotein C4 family					family	1	0	0	0
ARP2 subfamily					subfamily	1	1	1	1
ATRIP family					family	1	0	1	1
ARMT1 family					family	1	0	0	0
ATG7 family					family	1	1	0	0
ARPC4 family					family	1	0	1	0
alpha-casein family					family	1	0	0	0
AUP1 family					family	1	0	1	0
ARP6 subfamily					subfamily	1	0	0	0
APC8/CDC23 family					family	1	0	1	1
ACMSD family					family	1	0	1	1
ADRA1A sub-subfamily					subsubfamily	1	1	0	0
ATPase delta chain family					family	1	0	0	0
Agmatinase subfamily					subfamily	1	0	0	0
arsA ATPase family					family	1	0	0	0
ATG13 family					family	1	0	1	1
autoinducer-2 exporter (AI-2E) (TC 2.A.86) family					family	1	0	0	0
ASIC4 subfamily					subfamily	1	0	0	0
argininosuccinate synthase family					family	1	0	1	1
Alpha-4/CHRNA4 sub-subfamily					subsubfamily	1	1	1	1
ADRA2A sub-subfamily					subsubfamily	1	1	1	0
AFG1 ATPase family					family	1	0	0	0
AATF family					family	1	0	1	0
ABP1 family					family	1	0	1	0
ameloblastin family					family	1	0	0	0
AROS family					family	1	0	0	0
AAR2 family					family	1	0	0	0
APC15 family					family	1	0	1	0
A-like 1 sub-subfamily					subsubfamily	1	0	1	0
ATPase inhibitor family					family	1	0	0	0
APC13 family					family	1	0	1	0
archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family					family	1	0	1	0
ASCC2 family					family	1	0	1	0
archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family					family	1	0	1	0
ATPase d subunit family					family	1	0	0	0
ADRA2C sub-subfamily					subsubfamily	1	1	0	0
ACBP family					family	1	0	1	0
ANKH family					family	1	0	0	0
ADGF subfamily					subfamily	1	0	1	1
apolipoprotein C1 family					family	1	0	1	0
ARC/ARG3.1 family					family	1	0	0	0
anaerobic coproporphyrinogen-III oxidase family					family	1	0	0	0
acyl coenzyme A hydrolase family					family	1	0	0	0
apolipoprotein C2 family					family	1	0	1	0
ANGPTL8 family					family	1	0	0	0
ABCE family					family	1	0	0	0
ATPase F chain family					family	1	0	0	0
Alpha-10/CHRNA10 sub-subfamily					subsubfamily	1	1	0	0
ADRA1B sub-subfamily					subsubfamily	1	1	0	0
ALYREF family					family	1	0	1	0
ADRA2B sub-subfamily					subsubfamily	1	1	0	0
ATPase e subunit family					family	1	0	0	0
augurin family					family	1	0	0	0
ARL6ip family					family	1	0	0	0
APCDD1 family					family	1	0	0	0
Alax-L subfamily					subfamily	1	0	0	0
ATP11 family					family	1	0	0	0
ATCase/OTCase family					family	1	1	1	1
ASIC3 subfamily					subfamily	1	1	0	0
ACBD7 family					family	1	0	1	0
amphiregulin family					family	1	1	1	0
ATG37 family					family	1	0	1	1
ATG12 family					family	1	0	1	0
Abraxas subfamily					subfamily	1	0	1	0
ALG14 family					family	1	0	0	0
AVL9 family					family	1	0	0	0
ARP5 subfamily					subfamily	1	0	1	1
ALEX family					family	1	0	0	0
AMN1 family					family	1	0	0	0
asteroid family					family	1	0	0	0
ARPC3 family					family	1	0	1	1
ATZ/TRZ family					family	1	1	1	1
archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family					family	1	0	1	1
ARS2 family					family	1	0	1	1
ATPase A chain family					family	1	0	0	0
ARV1 family					family	1	0	0	0
archease family					family	1	0	0	0
aerobic coproporphyrinogen-III oxidase family					family	1	1	1	1
ashwin family					family	1	0	0	0
amelotin family					family	1	0	0	0
ADRA1D sub-subfamily					subsubfamily	1	1	0	0
Alpha-6/CHRNA6 sub-subfamily					subsubfamily	1	1	0	0
A-like 2 sub-subfamily					subsubfamily	1	0	0	0
apolipoprotein C3 family					family	1	0	1	0
ADRM1 family					family	1	0	1	1
ANKLE2 family					family	1	0	0	0
acetyltransferase ATAT1 family					family	1	0	1	1
amidinotransferase family					family	1	0	1	1
Alpha-5/CHRNA5 sub-subfamily					subsubfamily	1	1	0	0
allantoicase family					family	1	0	0	0
APC3/CDC27 family					family	1	0	1	1
AUNIP family					family	1	0	0	0
Alpha-1/CHRNA1 sub-subfamily					subsubfamily	1	1	1	0
alpha-2-MRAP family					family	1	0	1	0
AMPK subfamily					subfamily	1	1	0	0
Asterix family					family	1	0	0	0
ARMC6 family					family	1	0	0	0
ANF receptor family					family	1	1	1	1
ATP-specific subunit beta subfamily					subfamily	1	0	1	0
aromatic-ring hydroxylase family					family	1	1	1	1
ATPase protein 8 family					family	1	0	0	0
ANKZF1/VMS1 family					family	1	0	0	0
APC4 family					family	1	0	1	1
APC16 family					family	1	0	1	0
ARL6IP4 family					family	1	0	0	0
AAMDC family					family	1	0	1	0
ADAT3 subfamily					subfamily	1	0	0	0
AKNA family					family	1	0	0	0
ARPC2 family					family	1	0	0	0
ArgK/MeaB subfamily					subfamily	1	0	1	1