Protein Family Synopsis
Family Overview
Special Analysis

Rho family - Overview - Protein Family Synopsis

(PDB: 4F38)

Members
(human, all organisms)
20, 209
Drug targets
(human, all organisms)
0, 0
Members with known 3D structures
(human, all organisms)
12, 26
Members with tested compounds
(human, all organisms)
5, 6
Members with active compounds (<100nM)
(human, all organisms)
1, 1
Members with mutations reported
(human, all organisms)
20, 20

Lineage


small GTPase superfamily (159)
Arf family (27)
+ Unclassified (27)
ARL5C
ARF4
ARL2
ARL3
ARL1
ARL4A
ARL4D
ARL4C
ARF3
ARF6
ARF1
ARF5
ARL16
ARFRP1
ARL13B
ARL13A
ARL9
ARL17A,ARL17B
ARL14
ARL10
ARL11
ARL8A
ARL5B
ARL6
ARL8B
ARL15
ARL5A
Di-Ras family (3)
+ Unclassified (3)
DIRAS1
DIRAS3
DIRAS2
RGK family (4)
+ Unclassified (4)
REM1
GEM
RRAD
REM2
Rab family (73)
+ Unclassified (73)
RAB19
RAB27B
RAB29
RAB3D
RAB36
RAB40AL
RAB3A
RAB3B
RAB4A
RAB5A
RAB6A
RAB5C
RAB7A
RAB9A
RAB13
RAB28
RAB27A
RAB38
RAB25
RAB15
RAB8A
RAB4B
RAB2A
RAB5B
RAB10
RAB14
RAB11A
RAB1A
RAB40B
RAB31
RAB32
RAB33A
RAB39A
RAB35
RAB30
RAB11B
RABL6
RABL3
RAB41
RAB12
RAB44
RAB43
RASEF
RAB42
RAB2B
RAB40A
RAB1C
RAB8B
RAB24
RAB7B
RAB37
RAB39B
RAB3C
RAB40C
RSG1
IFT27
RAB34
RAB33B
RAB6C
RAB17
RAB1B
IFT22
RAB18
RAB9B
RAB6B
RAB20
DNAJC27
RABL2A
RAB21
RAB22A
RAB23
RAB26
RABL2B
Ran family (1)
+ Unclassified (1)
RAN
Ras family (25)
+ Unclassified (23)
MRAS
NRAS
HRAS
KRAS
RAP2A
RRAS
RALA
RALB
RAP1B
RAP2B
RRAS2
RAP1A
RASL11A
ERAS
RASL10A
RIT1
RERG
RASL10B
RIT2
RASL11B
RERGL
RASL12
RAP2C
+ KappaB-Ras subfamily (2)
NKIRAS1
NKIRAS2
RasD family (2)
+ Unclassified (2)
RASD2
RASD1
Rheb family (2)
+ Unclassified (2)
RHEB
RHEBL1
Rho family (20) *
+ Unclassified (19)
RHOD
RHOBTB1
RHOC
RAC2
RHOQ
RND2
RAC3
RHOA
RND3
RHOB
RAC1
RHOG
RHOH
RHOU
RND1
RHOV
RHOBTB2
RHOJ
RHOF
+ CDC42 subfamily (1)
CDC42
SAR1 family (2)
+ Unclassified (2)
SAR1A
SAR1B