Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

murI (Q9ZLT0) - Overview - Molecular Target Synopsis

Protein


murI, Glutamate racemase
Enzyme Classification 5.1.1.3
UniProt Q9ZLT0

Also Known as MURI_HELPJ, murI, glr

Provides the (R)-glutamate required for cell wall biosynthesis. Homodimer.

4B1F
DESIGN OF INHIBITORS OF HELICOBACTER PYLORI GLUTAMATE RACEMASE AS SELECTIVE ANTIBACTERIAL AGENTS: INCORPORATION OF IMIDAZOLES ONTO A CORE PYRAZOLOPYRIMIDINEDIONE SCAFFOLD TO IMPROVE BIOAVAILABILTY
RCSB/PDB
Inspect Structure
See all 3D Structures for murI

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
255Q9ZLT0-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project murI has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For murI there are:
5 structures (12 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


murI has been screened with 74 compounds (74 bioactivities), 46 compounds have bioactivities that show binding affinity of <= 500nM (46 bioactivities). (see details)