Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

polC (Q9ZHF6) - Overview - Molecular Target Synopsis

Protein


polC, DNA polymerase III PolC-type
Enzyme Classification 2.7.7.7
UniProt Q9ZHF6

Also Known as DPO3_THEMA, polC

Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.

2P1J
CRYSTAL STRUCTURE OF A POLC-TYPE DNA POLYMERASE III EXONUCLEASE DOMAIN FROM THERMOTOGA MARITIMA
RCSB/PDB
Inspect Structure
See all 3D Structures for polC

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1367Q9ZHF6-1

Sub-cellular localization


UniProt: polC is active in the following subcellular-locations: cytoplasm.
GO terms: polC is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project polC has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For polC there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


polC has been screened with compounds ( bioactivities). (see details)