Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAM2 (Q9Y765) - Overview - Molecular Target Synopsis

Protein


RAM2, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Enzyme Classification 2.5.1.58
UniProt Q9Y765

Also Known as FNTA_CANAX, RAM2

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Heterodimer of an alpha and a beta subunit.

4YDO
CRYSTAL STRUCTURE OF CANDIDA ALBICANS PROTEIN FARNESYLTRANSFERASE IN APO FORM
RCSB/PDB
Inspect Structure
See all 3D Structures for RAM2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
306Q9Y765-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project RAM2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RAM2 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAM2 has been screened with compounds ( bioactivities). (see details)