Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RPS6KL1 (Q9Y6S9) - Overview - Molecular Target Synopsis

Protein


RPS6KL1, Ribosomal protein S6 kinase-like 1
Enzyme Classification 2.7.11.1
UniProt Q9Y6S9

Also Known as RPKL1_HUMAN, RPS6KL1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: RPS6KL1 is active in the following subcellular-locations: ribosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RPS6KL1 has gain in 4 cell-lines, loss in 0 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HCT_15, 786_0, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCLC-21H, NCI-H187, NCI-H1155

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, HSMM

(see details)

RNA Interference


RPS6KL1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HS578T, H1299. (see details)

3D Structures


At greater than 35% identity similarity to RPS6KL1 there are:
31 structures (34 chains) solved
30 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RPS6KL1 has been screened with compounds ( bioactivities). (see details)