ROBO1 (Q9Y6N7) - Overview - Molecular Target Synopsis
ROBO1, Roundabout homolog 1
Also Known as ROBO1_HUMAN, ROBO1, DUTT1
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development. Homodimer. Dimerization is mediated by the extracellular domain and is independent of SLIT liganding (PubMed:24673457). Interacts with SLIT1 (By similarity). Interacts with SLIT2 (PubMed:10102268, PubMed:11404413, PubMed:17848514). Interacts with FLRT3 (PubMed:24560577). Interacts with MYO9B (via Rho-GAP domain) (PubMed:26529257).
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UniProt: ROBO1 is active in the following subcellular-locations: axon, cell membrane, cell projection, endoplasmic reticulum-golgi intermediate compartment membrane.
GO terms: ROBO1 is active in the following subcellular-locations: axon, cell surface, cytoplasm, endoplasmic reticulum-Golgi intermediate compartment membrane, integral component of plasma membrane, plasma membrane.