Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CSNK1G3 (Q9Y6M4) - Overview - Molecular Target Synopsis

Protein


CSNK1G3, Casein kinase I isoform gamma-3
Enzyme Classification 2.7.11.1
UniProt Q9Y6M4

Also Known as KC1G3_HUMAN, CSNK1G3

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Monomer.

6GRO
HUMAN CSNK1G3 BOUND TO SB-223133
RCSB/PDB
Inspect Structure
See all 3D Structures for CSNK1G3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CSNK1G3 is active in the following subcellular-locations: cytoplasm.
GO terms: CSNK1G3 is active in the following subcellular-locations: cytoplasm, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CSNK1G3 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, SF_539, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-144, HM7, OVCAR-8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)

RNA Interference


CSNK1G3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SKBR3, KNS42. (see details)

3D Structures


For CSNK1G3 there are:
10 structures (10 chains) solved
10 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CSNK1G3 has been screened with 761 compounds (1417 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (6 bioactivities). (see details)