Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CSNK1G3 (Q9Y6M4) - Overview - Molecular Target Synopsis


CSNK1G3, Casein kinase I isoform gamma-3
Enzyme Classification
UniProt Q9Y6M4

Also Known as KC1G3_HUMAN, CSNK1G3

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate. Monomer.

Inspect Structure
See all 3D Structures for CSNK1G3

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: CSNK1G3 is active in the following subcellular-locations: cytoplasm.
GO terms: CSNK1G3 is active in the following subcellular-locations: cytoplasm, nucleus, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CSNK1G3 has gain in 0 cell-lines, loss in 3 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, SF_539, LOXIMVI

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-144, HM7, OVCAR-8

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, AG445, HSMM

(see details)

RNA Interference

CSNK1G3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: SKBR3, KNS42. (see details)

3D Structures

For CSNK1G3 there are:
10 structures (10 chains) solved
10 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CSNK1G3 has been screened with 761 compounds (1417 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (6 bioactivities). (see details)