Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLCO1B1 (Q9Y6L6) - Overview - Molecular Target Synopsis

Protein


SLCO1B1, Solute carrier organic anion transporter family member 1B1
UniProt Q9Y6L6

Also Known as SO1B1_HUMAN, SLCO1B1, LST1, OATP1B1, OATP2, OATPC, SLC21A6

Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
691ENSG00000134538ENST00000256958ENSP00000256958Q9Y6L6-1

Sub-cellular localization


UniProt: SLCO1B1 is active in the following subcellular-locations: basolateral cell membrane.
GO terms: SLCO1B1 is active in the following subcellular-locations: basolateral plasma membrane, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLCO1B1 has gain in 14 cell-lines, loss in 5 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, NCI_H322M, SK_MEL_2

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, LN-18, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLCO1B1 has been screened with 2099 compounds (2557 bioactivities), 33 compounds have bioactivities that show binding affinity of <= 500nM (45 bioactivities). (see details)