Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK24 (Q9Y6E0) - Overview - Molecular Target Synopsis

Protein


STK24, Serine/threonine-protein kinase 24
Enzyme Classification 2.7.11.1
UniProt Q9Y6E0

Also Known as STK24_HUMAN, STK24, MST3, STK3

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Monomer (PubMed:20124694). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006). Interacts with PDCD10; this interaction is required for the association of STK24 with RIPOR1 (PubMed:27807006).

4QO9
MST3 IN COMPLEX WITH DANUSERTIB
RCSB/PDB
Inspect Structure
See all 3D Structures for STK24

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK24 is active in the following subcellular-locations: cytoplasm, membrane, nucleus.
GO terms: STK24 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, Golgi apparatus, membrane, nucleolus, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK24 has gain in 5 cell-lines, loss in 8 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, SW_620, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 206F, Calu-6, GTL-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HSMM, NHLF

(see details)

RNA Interference


STK24 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCC70, SCC90. (see details)

3D Structures


For STK24 there are:
28 structures (32 chains) solved
24 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

STK24 is solved in complex with the approved drug(s):

B49/SUNITINIB (4QMZ_A),
DB8/BOSUTINIB (4QMN_A),
1N1/DASATINIB (4QMS_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK24 has been screened with 452 compounds (711 bioactivities), 15 compounds have bioactivities that show binding affinity of <= 500nM (22 bioactivities). (see details)