Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK24 (Q9Y6E0) - Overview - Molecular Target Synopsis


STK24, Serine/threonine-protein kinase 24
Enzyme Classification
UniProt Q9Y6E0

Also Known as STK24_HUMAN, STK24, MST3, STK3

Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation (PubMed:27807006). Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Monomer (PubMed:20124694). Interacts with CTTNBP2NL (PubMed:18782753). Interacts with RIPOR1 (via C-terminus); this interaction occurs in a PDCD10-dependent and Rho-independent manner (PubMed:27807006). Interacts with PDCD10; this interaction is required for the association of STK24 with RIPOR1 (PubMed:27807006).

Inspect Structure
See all 3D Structures for STK24

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: STK24 is active in the following subcellular-locations: cytoplasm, membrane, nucleus.
GO terms: STK24 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, Golgi apparatus, membrane, nucleolus, nucleoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK24 has gain in 5 cell-lines, loss in 8 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: COLO205, SW_620, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 206F, Calu-6, GTL-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, HSMM, NHLF

(see details)

RNA Interference

STK24 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCC70, SCC90. (see details)

3D Structures

For STK24 there are:
28 structures (32 chains) solved
24 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

STK24 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK24 has been screened with 452 compounds (711 bioactivities), 15 compounds have bioactivities that show binding affinity of <= 500nM (22 bioactivities). (see details)