Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SAR1B (Q9Y6B6) - Overview - Molecular Target Synopsis

Protein


SAR1B, GTP-binding protein SAR1b
UniProt Q9Y6B6

Also Known as SAR1B_HUMAN, SAR1B, SARA2, SARB

Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex. Homodimer. Binds PREB. Part of the COPII coat complex. Binds to the cytoplasmic tails of target proteins in the endoplasmic reticulum.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SAR1B is active in the following subcellular-locations: endoplasmic reticulum membrane, golgi apparatus, golgi stack membrane.
GO terms: SAR1B is active in the following subcellular-locations: COPII vesicle coat, cytosol, endoplasmic reticulum, endoplasmic reticulum exit site, endoplasmic reticulum membrane, ER to Golgi transport vesicle membrane, Golgi cisterna membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SAR1B has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_539, SK_MEL_28, MDA_N

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MKN-45, NCI-H596, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


At greater than 90% identity similarity to SAR1B there are:
3 structures (6 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SAR1B has been screened with compounds ( bioactivities). (see details)