Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL5A (Q9Y689) - Overview - Molecular Target Synopsis

Protein


ARL5A, ADP-ribosylation factor-like protein 5A
UniProt Q9Y689

Also Known as ARL5A_HUMAN, ARL5A, ARFLP5, ARL5

Lacks ADP-ribosylation enhancing activity.

2H16
STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 5 (ARL5)
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL5A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: ARL5A is active in the following subcellular-locations: cytoplasm, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL5A has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, OVCAR_3, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SU-DHL-5, RL, Hep G2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, NHEK, MCF-7

(see details)

3D Structures


For ARL5A there are:
4 structures (8 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL5A has been screened with compounds ( bioactivities). (see details)