Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRPS18B (Q9Y676) - Overview - Molecular Target Synopsis

Protein


MRPS18B, 28S ribosomal protein S18b, mitochondrial
UniProt Q9Y676

Also Known as RT18B_HUMAN, MRPS18B, C6orf14

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mS40 has a zinc binding site.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
258ENSG00000204568ENST00000259873ENSP00000259873Q9Y676-1
121ENSG00000204568ENST00000506373ENSP00000445207

Sub-cellular localization


UniProt: MRPS18B is active in the following subcellular-locations: mitochondrion.
GO terms: MRPS18B is active in the following subcellular-locations: cell junction, mitochondrial inner membrane, mitochondrial small ribosomal subunit, mitochondrion, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRPS18B has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, UACC_257, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SU-DHL-1, KYSE-150, HCC4011

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, HSMM, HMEC

(see details)

3D Structures


At greater than 75% identity similarity to MRPS18B there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis