Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CPQ (Q9Y646) - Overview - Molecular Target Synopsis

Protein


CPQ, Carboxypeptidase Q
Enzyme Classification 3.4.17.-
UniProt Q9Y646

Also Known as CBPQ_HUMAN, CPQ, LCH1, PGCP

Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor. Homodimer. The monomeric form is inactive while the homodimer is active.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CPQ is active in the following subcellular-locations: endoplasmic reticulum, golgi apparatus, lysosome, secreted.
GO terms: CPQ is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, extracellular exosome, extracellular space, Golgi apparatus, intracellular membrane-bounded organelle, lysosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CPQ has gain in 13 cell-lines, loss in 2 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-157, Hs 578T, HT-144

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: BJ, NHLF, AG445

(see details)