Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

IRAK3 (Q9Y616) - Overview - Molecular Target Synopsis

Protein


IRAK3, Interleukin-1 receptor-associated kinase 3
Enzyme Classification 2.7.11.1
UniProt Q9Y616

Also Known as IRAK3_HUMAN, IRAK3

Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.

5UKE
NMR STRUCTURE OF MONOMERIC HUMAN IRAK-M DEATH DOMAIN R56D, Y61E MUTANT
RCSB/PDB
Inspect Structure
See all 3D Structures for IRAK3

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: IRAK3 is active in the following subcellular-locations: cytoplasm, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project IRAK3 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: ML-2, SIG-M5, SJCRH30

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD14-positive monocyte, SK-N-SH, HSMM

(see details)

RNA Interference


IRAK3 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HS578T, CAL120. (see details)

3D Structures


For IRAK3 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


IRAK3 has been screened with 110 compounds (148 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (13 bioactivities). (see details)