Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTL7A (Q9Y615) - Overview - Molecular Target Synopsis

Protein


ACTL7A, Actin-like protein 7A
UniProt Q9Y615

Also Known as ACL7A_HUMAN, ACTL7A

Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer.

2XQN
22 RESIDUE FRAGMENT OF
ACTIN-LIKE PROTEIN 7A
IN THE STRUCTURE OF
COMPLEX OF THE 2ND AND 3RD LIM DOMAINS OF TES WITH THE EVH1 DOMAIN OF MENA AND THE N-TERMINAL DOMAIN OF ACTIN-LIKE PROTEIN ARP7A
RCSB/PDB
Inspect Structure
See all 3D Structures for ACTL7A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
435ENSG00000187003ENST00000333999ENSP00000334300Q9Y615-1

Sub-cellular localization


UniProt: ACTL7A is active in the following subcellular-locations: cytoplasm, cytoskeleton, golgi apparatus, nucleus.
GO terms: ACTL7A is active in the following subcellular-locations: cytoplasm, cytoskeleton, Golgi apparatus, male germ cell nucleus, motile cilium, nucleus, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTL7A has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, HL_60, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ACTL7A there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTL7A has been screened with compounds ( bioactivities). (see details)