Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACTL7B (Q9Y614) - Overview - Molecular Target Synopsis

Protein


ACTL7B, Actin-like protein 7B
UniProt Q9Y614

Also Known as ACL7B_HUMAN, ACTL7B

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
452ENSG00000148156ENST00000374667ENSP00000363799
415Q9Y614-1

Sub-cellular localization


UniProt: ACTL7B is active in the following subcellular-locations: cytoplasm, cytoskeleton.
GO terms: ACTL7B is active in the following subcellular-locations: actin cytoskeleton, cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACTL7B has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HL_60, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: CPC-N, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ACTL7B there are:
84 structures (246 chains) solved
72 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ACTL7B has been screened with compounds ( bioactivities). (see details)