Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FLVCR1 (Q9Y5Y0) - Overview - Molecular Target Synopsis

Protein


FLVCR1, Feline leukemia virus subgroup C receptor-related protein 1
UniProt Q9Y5Y0

Also Known as FLVC1_HUMAN, FLVCR1, FLVCR

Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro., Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. Interacts with HPX.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
555ENSG00000162769ENST00000366971ENSP00000355938Q9Y5Y0-1
343ENSG00000162769ENST00000419102ENSP00000414680
279Q9Y5Y0-2

Sub-cellular localization


UniProt: FLVCR1 is active in the following subcellular-locations: cell membrane, mitochondrion membrane.
GO terms: FLVCR1 is active in the following subcellular-locations: integral component of plasma membrane, mitochondrial membrane, mitochondrion, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FLVCR1 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, NCI_H460, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-150, NCI-H727, DMS 454

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, K562, H1-hESC

(see details)