FLVCR1 (Q9Y5Y0) - Overview - Molecular Target Synopsis
FLVCR1, Feline leukemia virus subgroup C receptor-related protein 1
Also Known as FLVC1_HUMAN, FLVCR1, FLVCR
Isoform 1: Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies. Causes susceptibility to FeLV-C in vitro., Isoform 2: Heme transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. Interacts with HPX.
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UniProt: FLVCR1 is active in the following subcellular-locations: cell membrane, mitochondrion membrane.
GO terms: FLVCR1 is active in the following subcellular-locations: integral component of plasma membrane, mitochondrial membrane, mitochondrion, plasma membrane.