Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LIPG (Q9Y5X9) - Overview - Molecular Target Synopsis

Protein


LIPG, Endothelial lipase
Enzyme Classification 3.1.1.3
UniProt Q9Y5X9

Also Known as LIPE_HUMAN, LIPG

Has phospholipase and triglyceride lipase activities. Hydrolyzes high density lipoproteins (HDL) more efficiently than other lipoproteins. Binds heparin. Head to tail homodimer.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LIPG is active in the following subcellular-locations: secreted.
GO terms: LIPG is active in the following subcellular-locations: cell surface, early endosome, extracellular region, extracellular space, Golgi apparatus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LIPG has gain in 2 cell-lines, loss in 11 cell-lines and no signal in 992 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, HS578T, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GR-M, HCC1187, GP5d

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, HUVEC, HMEC

(see details)

3D Structures


At greater than 35% identity similarity to LIPG there are:
4 structures (12 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


LIPG has been screened with 692 compounds (744 bioactivities), 606 compounds have bioactivities that show binding affinity of <= 500nM (629 bioactivities). (see details)