Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

WIF1 (Q9Y5W5) - Overview - Molecular Target Synopsis

Protein


WIF1, Wnt inhibitory factor 1
UniProt Q9Y5W5

Also Known as WIF1_HUMAN, WIF1

Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Interacts with MYOC.

2YGN
WIF DOMAIN OF HUMAN WNT INHIBITORY FACTOR 1 IN COMPLEX WITH 1,2-DIPALMITOYLPHOSPHATIDYLCHOLINE
RCSB/PDB
Inspect Structure
See all 3D Structures for WIF1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: WIF1 is active in the following subcellular-locations: secreted.
GO terms: WIF1 is active in the following subcellular-locations: cell surface, extracellular region.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project WIF1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, M14

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H520, HCC1599, QGP-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures


For WIF1 there are:
5 structures (5 chains) solved
4 are solved in complex with at least one small molecule ligand
4 are solved with an approved drug

WIF1 is solved in complex with the approved drug(s):

PCF/COLFOSCERIL PALMITATE (2YGN_A, 2YGO_A, 2YGP_A, 2YGQ_A).

(see details)
Molecular Target 3D Synopsis