Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
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Ligand Efficiency Plot
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Gene Copy Number Variation
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TRPV2 (Q9Y5S1) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
2F37_B Transient receptor potential cation channel subfamily V member 2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.23 70.4 26.1 Yes Yes
2 empty 2.55 66.3 25.5 No No
3 empty 2.15 65.6 22.5 No No
4 bound 1.93 78 17.5 No No
5 empty 2.1 67.9 16.9 No No
6 bound 1.55 82.9 12.2 No No
7 empty 2.41 67.3 13.2 No No
8 empty 1.4 72.7 8.8 No No
9 bound 2.19 57.4 13.3 No No
10 empty 1.83 62.8 12.1 No No
2F37_A Transient receptor potential cation channel subfamily V member 2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.49 65.6 25.2 Yes No
2 empty 2.52 67.1 22 No No
3 empty 2.19 62.7 22.6 No No
4 empty 1.94 71 12.6 No No
5 empty 1.98 57.4 11.7 No No
6 empty 2.2 65.9 13.1 No No
7 empty 2.53 70.3 14.1 No No
8 empty 2.54 64.8 12.6 No No
9 empty 1.49 81.2 8.5 No No
10 empty 2.06 64 10.4 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2F37_A (3080882) Transient receptor potential cation channel subfamily V member 2 beta-hairpin-alpha-hairpin repeat, Ankyrin repeat, UNMATCHED 1.65Å Yes No
2F37_A (3080881) Transient receptor potential cation channel subfamily V member 2 TIM beta/alpha-barrel, Bacterial luciferase-like, Ssud-like monoxygenases 1.65Å No No
Ligand-based Druggability Score: -0.8
Ligand-based Druggability Score Percentile: 71%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


TRPV2 is involved in 2 interactions in the network.


Druggability
Overall Druggability Percentile: 86.83
Druggability for Cancer Therapeutics: 62.44
Druggability for Other Therapeutics: 76.22
Cancer-Associated
Cancer-associated percentile : 22.86
Network Articulation Point
Is TRPV2 critical for communication in the network?


Detailed Graph Legend:Help