Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRPV2 (Q9Y5S1) - Overview - Molecular Target Synopsis

Protein


TRPV2, Transient receptor potential cation channel subfamily V member 2
UniProt Q9Y5S1

Also Known as TRPV2_HUMAN, TRPV2, VRL

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation (By similarity).

2F37
CRYSTAL STRUCTURE OF THE ANKYRIN REPEAT DOMAIN OF HUMAN TRPV2
RCSB/PDB
Inspect Structure
See all 3D Structures for TRPV2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TRPV2 is active in the following subcellular-locations: cell membrane, cytoplasm, melanosome.
GO terms: TRPV2 is active in the following subcellular-locations: axonal growth cone, cell body, cell surface, growth cone membrane, integral component of plasma membrane, melanosome, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRPV2 has gain in 4 cell-lines, loss in 7 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, LOXIMVI, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-MEL-28, MDST8, NCI-H650

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, K562, IMR-90

(see details)

3D Structures


For TRPV2 there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TRPV2 has been screened with 4 compounds (5 bioactivities). (see details)