Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FADS3 (Q9Y5Q0) - Overview - Molecular Target Synopsis

Protein


FADS3, Fatty acid desaturase 3
Enzyme Classification 1.14.19.-
UniProt Q9Y5Q0

Also Known as FADS3_HUMAN, FADS3, CYB5RP

Acts as a methyl-end fatty acyl coenzyme A (CoA) desaturase that introduces a cis double bond between the preexisting double bond and the terminal methyl group of the fatty acyl chain. Desaturates (11E)-octadecenoate (trans-vaccenoate) at carbon 13 to generate (11E,13Z)-octadecadienoate, likely participating in the biohydrogenation pathway of linoleic acid (LA) (18:2n-6).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FADS3 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: FADS3 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FADS3 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, HS578T, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2452, NCI-H2373, BHY

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, HUVEC

(see details)


Screening and Chemistry


FADS3 has been screened with compounds ( bioactivities). (see details)