Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

COL4A3BP (Q9Y5P4) - Overview - Molecular Target Synopsis

Protein


COL4A3BP, Collagen type IV alpha-3-binding protein
UniProt Q9Y5P4

Also Known as C43BP_HUMAN, COL4A3BP, CERT, STARD11

Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner. Interacts with COL4A3. Interacts with VAPA and VAPB. Interaction with VAPB is less efficient than with VAPA.

6IEZ
CRYSTAL STRUCTURE OF CERT START DOMAIN IN COMPLEX WITH COMPOUND B16
RCSB/PDB
Inspect Structure
See all 3D Structures for COL4A3BP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: COL4A3BP is active in the following subcellular-locations: cytoplasm, endoplasmic reticulum, golgi apparatus.
GO terms: COL4A3BP is active in the following subcellular-locations: cell, cytosol, endoplasmic reticulum membrane, Golgi apparatus, membrane, mitochondrion, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project COL4A3BP has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: M14, MDA_MB_435, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HT-144, COLO 792, WM-115

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, GM12878

(see details)

RNA Interference


COL4A3BP was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CROE33, MDAMB436. (see details)

3D Structures


For COL4A3BP there are:
27 structures (35 chains) solved
23 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis