Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PPME1 (Q9Y570) - Overview - Molecular Target Synopsis

Protein


PPME1, Protein phosphatase methylesterase 1
Enzyme Classification 3.1.1.89
UniProt Q9Y570

Also Known as PPME1_HUMAN, PPME1, PME1

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. Binds PPP2CA and PPP2CB.

3C5W
COMPLEX BETWEEN PP2A-SPECIFIC METHYLESTERASE PME-1 AND PP2A CORE ENZYME
RCSB/PDB
Inspect Structure
See all 3D Structures for PPME1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: PPME1 is active in the following subcellular-locations: nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PPME1 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, NCI_H522, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LN-18, RERF-LC-OK, A172

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, SK-N-SH, BJ

(see details)

3D Structures


For PPME1 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PPME1 has been screened with 6 compounds (16 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)