Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP4K5 (Q9Y4K4) - Overview - Molecular Target Synopsis

Protein


MAP4K5, Mitogen-activated protein kinase kinase kinase kinase 5
Enzyme Classification 2.7.11.1
UniProt Q9Y4K4

Also Known as M4K5_HUMAN, MAP4K5

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. Interacts with both SH3 domains of the adapter proteins CRK and CRKL.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MAP4K5 is active in the following subcellular-locations: cytoplasm.
GO terms: MAP4K5 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP4K5 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: DU_145, SK_MEL_2, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, DU 145, KP4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, SK-N-SH, IMR-90

(see details)

RNA Interference


MAP4K5 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: LM7, SAOS2. (see details)

3D Structures


At greater than 75% identity similarity to MAP4K5 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAP4K5 has been screened with compounds ( bioactivities). (see details)