Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

DAGLA (Q9Y4D2) - Overview - Molecular Target Synopsis

Protein


DAGLA, Sn1-specific diacylglycerol lipase alpha
Enzyme Classification 3.1.1.-
UniProt Q9Y4D2

Also Known as DGLA_HUMAN, DAGLA, C11orf11, KIAA0659, NSDDR

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1042ENSG00000134780ENST00000257215ENSP00000257215Q9Y4D2-1
167ENSG00000134780ENST00000540717ENSP00000440264

Sub-cellular localization


UniProt: DAGLA is active in the following subcellular-locations: cell membrane.
GO terms: DAGLA is active in the following subcellular-locations: integral component of postsynaptic membrane, plasma membrane, postsynaptic membrane, varicosity.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project DAGLA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, T47D, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, NCI-H2795, SNU-216

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)


Screening and Chemistry


DAGLA has been screened with 282 compounds (353 bioactivities), 92 compounds have bioactivities that show binding affinity of <= 500nM (104 bioactivities). (see details)