Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

DAGLA (Q9Y4D2) - Overview - Molecular Target Synopsis


DAGLA, Sn1-specific diacylglycerol lipase alpha
Enzyme Classification 3.1.1.-
UniProt Q9Y4D2

Also Known as DGLA_HUMAN, DAGLA, C11orf11, KIAA0659, NSDDR

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: DAGLA is active in the following subcellular-locations: cell membrane.
GO terms: DAGLA is active in the following subcellular-locations: integral component of postsynaptic membrane, plasma membrane, postsynaptic membrane, varicosity.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project DAGLA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: A498, T47D, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 454, NCI-H2795, SNU-216

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

Screening and Chemistry

DAGLA has been screened with 251 compounds (315 bioactivities), 65 compounds have bioactivities that show binding affinity of <= 500nM (75 bioactivities). (see details)