WNK2 (Q9Y3S1) - Overview - Molecular Target Synopsis
WNK2, Serine/threonine-protein kinase WNK2
Enzyme Classification 188.8.131.52
Also Known as WNK2_HUMAN, WNK2, KIAA1760, PRKWNK2, SDCCAG43
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity. Forms a complex with the phosphorylated form of STK39.
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UniProt: WNK2 is active in the following subcellular-locations: cell membrane, cytoplasm.
GO terms: WNK2 is active in the following subcellular-locations: cytoplasm, cytosol, plasma membrane.