Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NEU2 (Q9Y3R4) - Overview - Molecular Target Synopsis

Protein


NEU2, Sialidase-2
Enzyme Classification 3.2.1.18
UniProt Q9Y3R4

Also Known as NEUR2_HUMAN, NEU2

Catalyzes the removal of sialic acid (N-acetylneuraminic acid) moities from glycoproteins, oligosaccharides and gangliosides.

4NCS
HUMAN SIALIDASE 2 IN COMPLEX WITH 2,3-DIFLUOROSIALIC ACID (COVALENT INTERMEDIATE)
RCSB/PDB
Inspect Structure
See all 3D Structures for NEU2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
380ENSG00000115488ENST00000233840ENSP00000233840Q9Y3R4-1

Sub-cellular localization


UniProt: NEU2 is active in the following subcellular-locations: cytoplasm.
GO terms: NEU2 is active in the following subcellular-locations: catalytic complex, cytoplasm, cytosol, intracellular membrane-bounded organelle, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NEU2 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, MCF7, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For NEU2 there are:
16 structures (20 chains) solved
11 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

NEU2 is solved in complex with the approved drug(s):

BCZ/PERAMIVIR (2F10_A),
ZMR/ZANAMIVIR (2F0Z_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NEU2 has been screened with 181 compounds (216 bioactivities). (see details)