Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HCN4 (Q9Y3Q4) - Overview - Molecular Target Synopsis

Protein


HCN4, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
UniProt Q9Y3Q4

Also Known as HCN4_HUMAN, HCN4

Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat. May contribute to the native pacemaker currents in neurons (Ih). May mediate responses to sour stimuli. Homotetramer. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits.

6GYN
STRUCTURE OF HUMAN HCN4 HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE- GATED ION CHANNEL
RCSB/PDB
Inspect Structure
See all 3D Structures for HCN4

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1203ENSG00000138622ENST00000261917ENSP00000261917Q9Y3Q4-1

Sub-cellular localization


UniProt: HCN4 is active in the following subcellular-locations: cell membrane.
GO terms: HCN4 is active in the following subcellular-locations: HCN channel complex, intrinsic component of plasma membrane, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HCN4 has gain in 3 cell-lines, loss in 2 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, RPMI_8226, OVCAR_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H187, VMRC-LCD, SCLC-22H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For HCN4 there are:
8 structures (18 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HCN4 has been screened with 58 compounds (66 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)