Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NAALAD2 (Q9Y3Q0) - Overview - Molecular Target Synopsis

Protein


NAALAD2, N-acetylated-alpha-linked acidic dipeptidase 2
Enzyme Classification 3.4.17.21
UniProt Q9Y3Q0

Also Known as NALD2_HUMAN, NAALAD2

Has N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Also exhibits a dipeptidyl-peptidase IV type activity. Inactivate the peptide neurotransmitter N-acetylaspartylglutamate. Homodimer.

3FEC
CRYSTAL STRUCTURE OF HUMAN GLUTAMATE CARBOXYPEPTIDASE III (GCPIII/NAALADASE II), PSEUDO-UNLIGANDED
RCSB/PDB
Inspect Structure
See all 3D Structures for NAALAD2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NAALAD2 is active in the following subcellular-locations: cell membrane.
GO terms: NAALAD2 is active in the following subcellular-locations: integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NAALAD2 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, KM12, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-DZ, C2BBe1, RERF-GC-1B

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For NAALAD2 there are:
4 structures (4 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


NAALAD2 has been screened with 20 compounds (20 bioactivities), 13 compounds have bioactivities that show binding affinity of <= 500nM (13 bioactivities). (see details)