Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STARD13 (Q9Y3M8) - Overview - Molecular Target Synopsis

Protein


STARD13, StAR-related lipid transfer protein 13
UniProt Q9Y3M8

Also Known as STA13_HUMAN, STARD13, DLC2, GT650

GTPase-activating protein for RhoA, and perhaps for Cdc42. May be involved in regulation of cytoskeletal reorganization, cell proliferation and cell motility. Acts a tumor suppressor in hepatocellular carcinoma cells. Homodimer. Interacts with TAX1BP1.

2JW2
VALIDATION OF INTER-HELICAL ORIENTATION OF THE STERIL-ALPHA- MOTIF OF HUMAN DELETED IN LIVER CANCER 2 BY RESIDUAL DIPOLAR COUPLINGS
RCSB/PDB
Inspect Structure
See all 3D Structures for STARD13

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STARD13 is active in the following subcellular-locations: cytoplasm, lipid droplet, membrane, mitochondrion membrane.
GO terms: STARD13 is active in the following subcellular-locations: cytosol, lipid droplet, mitochondrial membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STARD13 has gain in 6 cell-lines, loss in 4 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, T47D, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TC-71, SW 1463, SCC-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, IMR-90

(see details)

3D Structures


For STARD13 there are:
3 structures (5 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis