Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAP2C (Q9Y3L5) - Overview - Molecular Target Synopsis

Protein


RAP2C, Ras-related protein Rap-2c
UniProt Q9Y3L5

Also Known as RAP2C_HUMAN, RAP2C

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
183ENSG00000123728ENST00000370874, ENST00000342983ENSP00000359911, ENSP00000340274Q9Y3L5-1, Q8BU31-1, Q08DI5-1

Sub-cellular localization


UniProt: RAP2C is active in the following subcellular-locations: cytoplasm, recycling endosome membrane.
GO terms: RAP2C is active in the following subcellular-locations: bicellular tight junction, cell-cell contact zone, cytoplasm, cytosol, extracellular exosome, plasma membrane, recycling endosome membrane, tertiary granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAP2C has gain in 0 cell-lines, loss in 28 cell-lines and no signal in 977 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: BT_549, SNB_19, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-453, BT-20, Okajima

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, AG445

(see details)

3D Structures


At greater than 90% identity similarity to RAP2C there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAP2C has been screened with compounds ( bioactivities). (see details)