Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAP2C (Q9Y3L5) - Overview - Molecular Target Synopsis


RAP2C, Ras-related protein Rap-2c
UniProt Q9Y3L5

Also Known as RAP2C_HUMAN, RAP2C

Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May play a role in SRE-mediated gene transcription.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
183ENSG00000123728ENST00000370874, ENST00000342983ENSP00000359911, ENSP00000340274Q9Y3L5-1, Q8BU31-1, Q08DI5-1

Sub-cellular localization

UniProt: RAP2C is active in the following subcellular-locations: cytoplasm, recycling endosome membrane.
GO terms: RAP2C is active in the following subcellular-locations: bicellular tight junction, cell-cell contact zone, cytoplasm, cytosol, extracellular exosome, plasma membrane, recycling endosome membrane, tertiary granule membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAP2C has gain in 0 cell-lines, loss in 28 cell-lines and no signal in 977 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: BT_549, SNB_19, SW_620

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-453, BT-20, Okajima

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, MCF-7, AG445

(see details)

3D Structures

At greater than 90% identity similarity to RAP2C there are:
3 structures (4 chains) solved
3 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAP2C has been screened with compounds ( bioactivities). (see details)