Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MRPS18C (Q9Y3D5) - Overview - Molecular Target Synopsis


MRPS18C, 28S ribosomal protein S18c, mitochondrial
UniProt Q9Y3D5

Also Known as RT18C_HUMAN, MRPS18C

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. bS18m has a zinc binding site.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: MRPS18C is active in the following subcellular-locations: mitochondrion.
GO terms: MRPS18C is active in the following subcellular-locations: mitochondrial inner membrane, mitochondrial small ribosomal subunit.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MRPS18C has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MCF7, CCRF_CEM, MOLT_4

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: A-375, TYK-nu.CP-r, CW-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, MCF-7, SK-N-SH

(see details)

3D Structures

At greater than 75% identity similarity to MRPS18C there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis