Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

LUC7L2 (Q9Y383) - Overview - Molecular Target Synopsis

Protein


LUC7L2, Putative RNA-binding protein Luc7-like 2
UniProt Q9Y383

Also Known as LC7L2_HUMAN, LUC7L2

May bind to RNA via its Arg/Ser-rich domain. Interacts with SCNM1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: LUC7L2 is active in the following subcellular-locations: nucleoplasm, nucleus, nucleus speckle.
GO terms: LUC7L2 is active in the following subcellular-locations: nuclear speck, U1 snRNP, U2-type prespliceosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project LUC7L2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, MOLT_4, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to LUC7L2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis