Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CAB39 (Q9Y376) - Overview - Molecular Target Synopsis

Protein


CAB39, Calcium-binding protein 39
UniProt Q9Y376

Also Known as CAB39_HUMAN, CAB39, MO25

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.

4NZW
CRYSTAL STRUCTURE OF STK25-MO25 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for CAB39

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


UniProt: CAB39 is active in the following subcellular-locations: cytoplasm.
GO terms: CAB39 is active in the following subcellular-locations: cytosol, extracellular exosome, extracellular region, ficolin-1-rich granule lumen, secretory granule lumen, serine/threonine protein kinase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CAB39 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, MDA_N, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: EBC-1, Hs 746T, NCI-H2009

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HMEC, NHEK

(see details)

3D Structures


For CAB39 there are:
9 structures (11 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis