Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACOT9 (Q9Y305) - Overview - Molecular Target Synopsis

Protein


ACOT9, Acyl-coenzyme A thioesterase 9, mitochondrial
Enzyme Classification 3.1.2.-
UniProt Q9Y305

Also Known as ACOT9_HUMAN, ACOT9

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. Interacts with NYAP1, NYAP2 and MYO16.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACOT9 is active in the following subcellular-locations: mitochondrion.
GO terms: ACOT9 is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACOT9 has gain in 1 cell-lines, loss in 48 cell-lines and no signal in 956 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_268, NCI_H522, BT_549

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, LCLC-103H, AGS

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)