Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

YARS2 (Q9Y2Z4) - Overview - Molecular Target Synopsis

Protein


YARS2, Tyrosine--tRNA ligase, mitochondrial
Enzyme Classification 6.1.1.1
UniProt Q9Y2Z4

Also Known as SYYM_HUMAN, YARS2

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr). Homodimer.

3ZXI
CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL TYROSYL-TRNA SYNTHETASE IN COMPLEX WITH A TYROSYL-ADENYLATE ANALOG
RCSB/PDB
Inspect Structure
See all 3D Structures for YARS2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
477ENSG00000139131ENST00000324868ENSP00000320658Q9Y2Z4-1
291ENSG00000139131ENST00000548490ENSP00000447710

Sub-cellular localization


UniProt: YARS2 is active in the following subcellular-locations: mitochondrion matrix.
GO terms: YARS2 is active in the following subcellular-locations: cytosol, mitochondrial matrix, mitochondrion, nuclear body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project YARS2 has gain in 16 cell-lines, loss in 3 cell-lines and no signal in 986 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, NCI_H322M, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: RKN, NCI-H322T, GTL-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, A549, HeLa-S3

(see details)

3D Structures


For YARS2 there are:
2 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


YARS2 has been screened with compounds ( bioactivities). (see details)