Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL2BP (Q9Y2Y0) - Overview - Molecular Target Synopsis

Protein


ARL2BP, ADP-ribosylation factor-like protein 2-binding protein
UniProt Q9Y2Y0

Also Known as AR2BP_HUMAN, ARL2BP, BART, BART1

Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2. Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4. Interacts with GTP-bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for targeting to cilia basal body. Interacts with STAT3; interaction is enhanced with ARL2.

3DOE
COMPLEX OF ARL2 AND BART, CRYSTAL FORM 1
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL2BP

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ARL2BP is active in the following subcellular-locations: centrosome, cilium basal body, cytoplasm, cytoskeleton, microtubule organizing center, mitochondrion intermembrane space, nucleus, spindle.
GO terms: ARL2BP is active in the following subcellular-locations: centrosome, cilium, cytosol, midbody, mitochondrial intermembrane space, mitochondrial matrix, nucleus, spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL2BP has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_19, NCI_H460, SF_295

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-1, SiHa, MG-63

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)

3D Structures


For ARL2BP there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis