Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GDA (Q9Y2T3) - Overview - Molecular Target Synopsis

Protein


GDA, Guanine deaminase
Enzyme Classification 3.5.4.3
UniProt Q9Y2T3

Also Known as GUAD_HUMAN, GDA, KIAA1258

Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Homodimer.

4AQL
HUMAN GUANINE DEAMINASE IN COMPLEX WITH VALACYCLOVIR
RCSB/PDB
Inspect Structure
See all 3D Structures for GDA

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: GDA is active in the following subcellular-locations: cytosol, intracellular.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GDA has gain in 1 cell-lines, loss in 4 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H460, IGROV1, OVCAR_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 837, MKN-1, RMG-I

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, NHLF

(see details)

3D Structures


For GDA there are:
3 structures (4 chains) solved
2 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

GDA is solved in complex with the approved drug(s):

TXC/VALACYCLOVIR (4AQL_A).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GDA has been screened with 15 compounds (18 bioactivities). (see details)