Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTK1 (Q9Y2Q3) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed11
Chains with at least one site assessed as druggable using the strict criteria8
Chains with at least one site assessed as druggable using the relaxed criteria11


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3RPN_B Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 74.5 31.3 Yes Yes
2 empty 2.38 66.2 33.7 No No
3 empty 2.12 66.4 22.1 No No
4 empty 1.86 61.8 24.6 No No
5 empty 2.13 62.4 22.6 No No
6 empty 2.16 59.5 14.6 No No
7 empty 2.01 65 12.7 No No
8 empty 2.39 56.8 16.8 No No
9 empty 1.74 81.9 9.1 No No
10 empty 2.5 58.3 14.1 No No
3RPP_C Glutathione S-transferase kappa 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.5 64.9 38.7 Yes No
2 empty 2.24 68.3 27.9 No No
3 empty 2.1 58.2 16 No No
4 empty 2.26 63.8 19.2 No No
5 empty 2.14 67.4 12.8 No No
6 empty 2.34 58 14.2 No No
7 empty 2.4 59.6 14.4 No No
8 empty 2.04 78.1 11 No No
9 empty 2.17 54.2 12.9 No No
10 empty 2.54 62.1 9.8 No No
3RPN_F Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 70.8 39.1 Yes Yes
2 empty 2.56 66.5 33.2 No No
3 empty 2.18 70.6 15 No No
4 empty 2.21 61.1 14.4 No No
5 empty 2.44 59.4 8.7 No No
6 empty 2.42 56.5 10.7 No No
7 empty 2.06 69.3 11.8 No No
8 empty 2.12 64.9 10.4 No No
9 empty 1.25 66.9 7.2 No No
10 empty 2.63 59 9.7 No No
3RPP_A Glutathione S-transferase kappa 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.54 65.7 38.9 Yes No
2 empty 2.34 66 29.8 No No
3 empty 2.15 56.7 18 No No
4 empty 2.11 55.8 15.8 No No
5 empty 2.11 68.2 11.6 No No
6 empty 2.16 62.7 12.6 No No
7 empty 1.91 81.9 11.5 No No
8 empty 2.24 60.7 9.5 No No
9 empty 2.18 54.8 12.3 No No
10 empty 2.41 56.1 14.4 No No
3RPN_C Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 77 30.6 Yes Yes
2 empty 2.37 64 32.3 No No
3 empty 2.01 68.8 18 No No
4 empty 1.24 71 14.7 No No
5 empty 2.07 77.5 11.3 No No
6 empty 2.09 58.5 13.6 No No
7 empty 2.15 61.8 14.2 No No
8 empty 2.14 61.6 16.6 No No
9 empty 1.91 62.7 12.3 No No
10 empty 2.47 57 9.6 No No
1YZX_A Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 70.2 44.3 Yes Yes
2 empty 2.38 62.2 25.5 No No
3 empty 2.1 70.7 16.8 No No
4 empty 2.2 65.4 21 No No
5 empty 2.29 58.2 13.6 No No
6 empty 2.68 61 10.6 No No
7 empty 2.14 83.2 7.8 No No
8 empty 2.43 45.3 9.8 No No
9 empty 2.52 60.6 7.8 No No
10 empty 2.42 61.3 8.7 No No
3RPP_B Glutathione S-transferase kappa 1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.28 65.7 40.1 Yes No
2 empty 2.41 63.2 23.8 No No
3 empty 2.18 60.2 19 No No
4 empty 2.22 57.7 16.3 No No
5 empty 2.33 74.2 13.1 No No
6 empty 2.5 68.9 12.1 No No
7 empty 2.12 63 14.5 No No
8 empty 2.22 57.5 14 No No
9 empty 2.1 53.7 12.2 No No
10 empty 2.32 62.4 8.2 No No
3RPN_D Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.99 71 44 Yes Yes
2 empty 2.36 61.8 24.5 No No
3 empty 2.16 61.4 14.5 No No
4 empty 2.13 57.8 14.2 No No
5 empty 2.34 58.2 10.7 No No
6 empty 2 67.8 10.3 No No
7 empty 2.28 58.5 11.1 No No
8 empty 2.06 60.8 7.3 No No
9 empty 2.79 62.5 8.4 No No
10 empty 2.45 58.4 9.4 No No
3RPN_E Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 72.4 34.7 Yes Yes
2 empty 2.39 62.2 32.9 No No
3 empty 2.05 67.6 21.1 No No
4 empty 2.45 65.5 17.7 No No
5 empty 2.05 61.6 10.9 No No
6 empty 2.36 54.2 12.1 No No
7 empty 2.45 54.7 9.8 No No
8 empty 2.33 55.5 10.6 No No
9 empty 2.17 76.2 9.6 No No
10 empty 2.47 56.7 8.7 No No
1YZX_B Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 68.8 44.3 Yes Yes
2 empty 2.39 62.7 32.2 No No
3 empty 1.99 70.9 18.8 No No
4 empty 2.47 58.8 13 No No
5 empty 2.3 61 16.6 No No
6 empty 2.64 58.3 10.1 No No
7 empty 2.22 79.8 7.9 No No
8 empty 2.42 67.1 8.2 No No
9 empty 2.37 56.1 9.7 No No
10 empty 2.1 79 9.1 No No
3RPN_A Glutathione S-transferase kappa 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 74.2 27 Yes Yes
2 empty 2.32 63.6 33.1 No No
3 empty 2.2 66.5 22.1 No No
4 empty 1.86 62.5 24.7 No No
5 empty 2.14 62 22.5 No No
6 empty 2.11 57.5 15.2 No No
7 empty 2.56 61 20 No No
8 empty 1.84 79.6 10.5 No No
9 empty 2.31 62.8 12.3 No No
10 empty 2.81 68.8 12.2 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed8
Domains assessed as druggable using the strict criteria5
Domains assessed as druggable using the relaxed criteria8

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1YZX_B (4102811) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.86Å Yes Yes
1YZX_A (4102811) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.86Å Yes Yes
1YZX_A (3030293) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, UNMATCHED 1.86Å Yes No
3RPN_F (4199358) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
3RPN_B (4221429) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
3RPN_A (4093657) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
3RPN_D (4093657) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
3RPN_A (3700255) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, UNMATCHED 1.8Å Yes No
3RPN_C (4199358) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
3RPN_E (4221429) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
3RPP_A (3700256) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, UNMATCHED 1.8Å Yes No
3RPP_B (4251285) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
3RPP_C (4251285) Glutathione S-transferase kappa 1 Thioredoxin fold, Thioredoxin-like, DsbA-like (Homo Multimer) 1.8Å Yes Yes
Ligand-based Druggability Score: -1.55
Ligand-based Druggability Score Percentile: 63%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


GSTK1 is involved in 6 interactions in the network.


Druggability
Overall Druggability Percentile: 70.65
Druggability for Cancer Therapeutics: 94.02
Druggability for Other Therapeutics: 56.51
Cancer-Associated
Cancer-associated percentile : 58.43
Network Articulation Point
Is GSTK1 critical for communication in the network?


Detailed Graph Legend:Help