Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTK1 (Q9Y2Q3) - Overview - Molecular Target Synopsis

Protein


GSTK1, Glutathione S-transferase kappa 1
Enzyme Classification 2.5.1.18
UniProt Q9Y2Q3

Also Known as GSTK1_HUMAN, GSTK1

Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB). Homodimer.

3RPN
CRYSTAL STRUCTURE OF HUMAN KAPPA CLASS GLUTATHIONE TRANSFERASE IN COMPLEX WITH S-HEXYLGLUTATHIONE
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTK1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTK1 is active in the following subcellular-locations: peroxisome.
GO terms: GSTK1 is active in the following subcellular-locations: cytosol, extracellular exosome, intracellular, membrane, mitochondrial matrix, mitochondrion, peroxisomal matrix, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTK1 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, OVCAR_4, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HM7, SK23, RERF-LC-KJ

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, NHLF

(see details)

3D Structures


For GSTK1 there are:
3 structures (11 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTK1 has been screened with 18 compounds (55 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)