Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC27A5 (Q9Y2P5) - Overview - Molecular Target Synopsis

Protein


SLC27A5, Bile acyl-CoA synthetase
Enzyme Classification 6.2.1.7
UniProt Q9Y2P5

Also Known as S27A5_HUMAN, SLC27A5, ACSB, ACSVL6, FACVL3, FATP5

Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
690ENSG00000083807ENST00000263093ENSP00000263093Q9Y2P5-1
606ENSG00000083807ENST00000601355ENSP00000470368Q9Y2P5-2

Sub-cellular localization


UniProt: SLC27A5 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: SLC27A5 is active in the following subcellular-locations: basal plasma membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral component of endoplasmic reticulum membrane, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC27A5 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, UACC_62, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MT-3, TMD8, LS 174T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, HMEC

(see details)


Screening and Chemistry


SLC27A5 has been screened with 42 compounds (42 bioactivities). (see details)