SLC27A5 (Q9Y2P5) - Overview - Molecular Target Synopsis
SLC27A5, Bile acyl-CoA synthetase
Enzyme Classification 184.108.40.206
Also Known as S27A5_HUMAN, SLC27A5, ACSB, ACSVL6, FACVL3, FATP5
Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol.
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UniProt: SLC27A5 is active in the following subcellular-locations: endoplasmic reticulum membrane.
GO terms: SLC27A5 is active in the following subcellular-locations: basal plasma membrane, endoplasmic reticulum, endoplasmic reticulum membrane, integral component of endoplasmic reticulum membrane, protein-containing complex.