Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC27A6 (Q9Y2P4) - Overview - Molecular Target Synopsis

Protein


SLC27A6, Long-chain fatty acid transport protein 6
UniProt Q9Y2P4

Also Known as S27A6_HUMAN, SLC27A6, ACSVL2, FACVL2, FATP1

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC27A6 is active in the following subcellular-locations: cell membrane, membrane, sarcolemma.
GO terms: SLC27A6 is active in the following subcellular-locations: integral component of membrane, plasma membrane, sarcolemma.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC27A6 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, HCT_116, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1568, OCI-M1, Hs 675.T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC27A6 has been screened with compounds ( bioactivities). (see details)