Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ZKSCAN5 (Q9Y2L8) - Overview - Molecular Target Synopsis

Protein


ZKSCAN5, Zinc finger protein with KRAB and SCAN domains 5
UniProt Q9Y2L8

Also Known as ZKSC5_HUMAN, ZKSCAN5, KIAA1015, ZFP95

May be involved in transcriptional regulation.

2YSO
SOLUTION STRUCTURE OF THE C2H2 TYPE ZINC FINGER (REGION 656- 688) OF HUMAN ZINC FINGER PROTEIN 95 HOMOLOG
RCSB/PDB
Inspect Structure
See all 3D Structures for ZKSCAN5

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ZKSCAN5 is active in the following subcellular-locations: nucleus.
GO terms: ZKSCAN5 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ZKSCAN5 has gain in 9 cell-lines, loss in 1 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, MDA_MB_231, K_562

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H322T, H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, SK-N-SH

(see details)

3D Structures


For ZKSCAN5 there are:
9 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ZKSCAN5 has been screened with compounds ( bioactivities). (see details)