Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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Germline Genetics

STK38L (Q9Y2H1) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed2
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5XQZ_C Serine/threonine-protein kinase 38-like Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 61.4 31.2 Yes No
2 empty 2.11 66.2 12.4 No No
3 empty 2.52 55.3 13.3 No No
4 empty 2.35 83.6 8.4 No No
5 empty 2.7 63.2 9.6 No No
6 empty 2.27 66 6 No No
7 empty 1.55 66.2 5.2 No No
8 empty 2.27 53.6 4.8 No No
9 empty 2.81 67.8 5.3 No No
10 empty 3.04 78.1 0 No No
5XQZ_D Serine/threonine-protein kinase 38-like Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 59.9 27.9 Yes No
2 empty 2.09 61.8 10.5 No No
3 empty 2.75 58 8.1 No No
4 empty 2.65 67.4 10.5 No No
5 empty 1.96 53.8 11.3 No No
6 empty 1.82 56 8.9 No No
7 empty 2.33 58.8 8.2 No No
8 empty 2.53 55.5 7.7 No No
9 empty 2.93 72.9 0 No No
10 empty 2.88 62.8 6.7 No No
Ligand-based Druggability Score: -0.65
Ligand-based Druggability Score Percentile: 72%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


STK38L is involved in 6 interactions in the network.


Druggability
Overall Druggability Percentile: 66.64
Druggability for Cancer Therapeutics: 67.85
Druggability for Other Therapeutics: 60.64
Cancer-Associated
Cancer-associated percentile : 54.16
Network Articulation Point
Is STK38L critical for communication in the network?


Detailed Graph Legend:Help