Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

STK38L (Q9Y2H1) - Overview - Molecular Target Synopsis


STK38L, Serine/threonine-protein kinase 38-like
Enzyme Classification
UniProt Q9Y2H1

Also Known as ST38L_HUMAN, STK38L, KIAA0965, NDR2

Involved in the regulation of structural processes in differentiating and mature neuronal cells. Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.

Inspect Structure
See all 3D Structures for STK38L

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: STK38L is active in the following subcellular-locations: cytoplasm, cytoskeleton, membrane.
GO terms: STK38L is active in the following subcellular-locations: actin cytoskeleton, cytoplasm, cytosol, membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project STK38L has gain in 27 cell-lines, loss in 3 cell-lines and no signal in 975 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SW_620, SF_539, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GTL-16, BEN, LS1034

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, NHLF, GM12878

(see details)

RNA Interference

STK38L was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: G292, SKGT4. (see details)

3D Structures

For STK38L there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

STK38L has been screened with 134 compounds (192 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)