Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

STK38L (Q9Y2H1) - Overview - Molecular Target Synopsis

Protein


STK38L, Serine/threonine-protein kinase 38-like
Enzyme Classification 2.7.11.1
UniProt Q9Y2H1

Also Known as ST38L_HUMAN, STK38L, KIAA0965, NDR2

Involved in the regulation of structural processes in differentiating and mature neuronal cells. Homodimeric S100B binds two molecules of STK38L. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4 (By similarity). Interacts with MOB1 and MOB2.

5XQZ
STRUCTURE OF THE MOB1-NDR2 COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for STK38L

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: STK38L is active in the following subcellular-locations: cytoplasm, cytoskeleton, membrane.
GO terms: STK38L is active in the following subcellular-locations: actin cytoskeleton, cytoplasm, cytosol, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project STK38L has gain in 27 cell-lines, loss in 3 cell-lines and no signal in 975 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SW_620, SF_539, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: GTL-16, BEN, LS1034

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, NHLF, GM12878

(see details)

RNA Interference


STK38L was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: G292, SKGT4. (see details)

3D Structures


For STK38L there are:
1 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


STK38L has been screened with 134 compounds (192 bioactivities), 2 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)