Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLC17A4 (Q9Y2C5) - Overview - Molecular Target Synopsis

Protein


SLC17A4, Probable small intestine urate exporter
UniProt Q9Y2C5

Also Known as S17A4_HUMAN, SLC17A4

Acts as a membrane potential-dependent organic anion transporter, the transport requires a low concentration of chloride ions. May be involved in urate extrusion from the intestinal duct. May recognize hydrophilic anionic drugs such as aspirin, salicylate, and ibuprofen as substrates. Able to actively transport inorganic phosphate into cells via Na(+) cotransport (in vitro).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLC17A4 is active in the following subcellular-locations: apical cell membrane, cell membrane.
GO terms: SLC17A4 is active in the following subcellular-locations: apical plasma membrane, integral component of membrane, integral component of plasma membrane, lysosome, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLC17A4 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_92, TK_10, SK_MEL_2

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)


Screening and Chemistry


SLC17A4 has been screened with compounds ( bioactivities). (see details)