Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RNF6 (Q9Y252) - Overview - Molecular Target Synopsis


RNF6, E3 ubiquitin-protein ligase RNF6
Enzyme Classification
UniProt Q9Y252

Also Known as RNF6_HUMAN, RNF6, SPG2

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Interacts with LIMK1 (By similarity). Interacts with AR.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: RNF6 is active in the following subcellular-locations: axon, cell projection, cytoplasm, nucleus, pml body.
GO terms: RNF6 is active in the following subcellular-locations: axon, cytoplasm, intracellular membrane-bounded organelle, nuclear membrane, nucleoplasm, nucleus, PML body.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RNF6 has gain in 4 cell-lines, loss in 5 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: COLO205, HL_60, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 205, HT-29, MKN-45

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, NHEK

(see details)

3D Structures

At greater than 35% identity similarity to RNF6 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis