Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RNF6 (Q9Y252) - Overview - Molecular Target Synopsis

Protein


RNF6, E3 ubiquitin-protein ligase RNF6
Enzyme Classification 2.3.2.27
UniProt Q9Y252

Also Known as RNF6_HUMAN, RNF6, SPG2

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Interacts with LIMK1 (By similarity). Interacts with AR.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RNF6 is active in the following subcellular-locations: axon, cell projection, cytoplasm, nucleus, pml body.
GO terms: RNF6 is active in the following subcellular-locations: axon, cytoplasm, intracellular membrane-bounded organelle, nuclear membrane, nucleoplasm, nucleus, PML body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RNF6 has gain in 4 cell-lines, loss in 5 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, HL_60, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 205, HT-29, MKN-45

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, NHEK

(see details)

3D Structures


At greater than 35% identity similarity to RNF6 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis