RNF6 (Q9Y252) - Overview - Molecular Target Synopsis
RNF6, E3 ubiquitin-protein ligase RNF6
Enzyme Classification 188.8.131.52
Also Known as RNF6_HUMAN, RNF6, SPG2
E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator. Interacts with LIMK1 (By similarity). Interacts with AR.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|685||ENSG00000127870||ENST00000346166, ENST00000381570, ENST00000381588||ENSP00000342121, ENSP00000370982, ENSP00000371000||Q9Y252-1|
UniProt: RNF6 is active in the following subcellular-locations: axon, cell projection, cytoplasm, nucleus, pml body.
GO terms: RNF6 is active in the following subcellular-locations: axon, cytoplasm, intracellular membrane-bounded organelle, nuclear membrane, nucleoplasm, nucleus, PML body.