Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

APOBEC2 (Q9Y235) - Overview - Molecular Target Synopsis

Protein


APOBEC2, C->U-editing enzyme APOBEC-2
Enzyme Classification 3.5.4.36
UniProt Q9Y235

Also Known as ABEC2_HUMAN, APOBEC2

Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. Homotetramer.

2NYT
THE APOBEC2 CRYSTAL STRUCTURE AND FUNCTIONAL IMPLICATIONS FOR AID
RCSB/PDB
Inspect Structure
See all 3D Structures for APOBEC2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
224ENSG00000124701ENST00000244669ENSP00000244669Q9Y235-1

Sub-cellular localization


GO terms: APOBEC2 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project APOBEC2 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: M14, HOP_92, EKVX

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO-704, SNU-620, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, GM12878, SK-N-SH

(see details)

3D Structures


For APOBEC2 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis